Central Alerting System Homepage


The Central Alerting System (CAS) is a web-based cascading system for issuing patient safety alerts, important public health messages and other safety critical information and guidance to the NHS and others, including independent providers of health and social care.

Alerts available on the CAS website include National Patient Safety Alerts (from NHS England and NHS Improvement and MHRA), NHS England and NHS Improvement Estates Alerts, MHRA Drug Alerts, Chief Medical Officer (CMO) Alerts, and Department of Health & Social Care Supply Disruption alerts.

Useful links:

National Patient Safety Alerts: https://www.england.nhs.uk/patient-safety/patient-safety-alerts/

The Medicines and Healthcare products Regulatory Agency: http://gov.uk/mhra

NHS Improvement: https://improvement.nhs.uk/resources/patient-safety-alerts/

The Chief Medical Officer (for England): https://www.gov.uk/government/people/christopher-whitty

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EL(20)A/45 - there was an error with the EU ref number for Vimpat 100mg Tablets in the alert (specifically in Tables 2, 3 and 4 – the latter EU ref should state EU/1/08/470/005 and not EU/1/05/331/005). The alert pdf has been updated accordingly and can be accessed via the 'Search alerts' link above.

Extended deadlines: given the current situation we have agreed with alert originators to extend the action completion deadlines for a number of alerts, we may add to this list in the coming weeks:

MDA/2020/005 - extended to 24 July 2020
EFA/2019/005 - extended to 30 October 2020
EFA 2020/00 ...
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Contact our helpdesk

Email: safetyalerts@mhra.gov.uk

Medicines and Healthcare products Regulatory Agency