Central Alerting System Homepage


The Central Alerting System (CAS) is a web-based cascading system for issuing patient safety alerts, important public health messages and other safety critical information and guidance to the NHS and others, including independent providers of health and social care.

Alerts available on the CAS website include NHS Improvement Patient Safety Alerts (PSA) and Estates Alerts, MHRA Dear Doctor letters, Medical Device Alerts (MDA) and Drug Alerts, Chief Medical Officer (CMO) Alerts, and Department of Health & Social Care Supply Disruption alerts.

Useful links:

The Medicines and Healthcare products Regulatory Agency: http://gov.uk/mhra

NHS Improvement: https://improvement.nhs.uk/resources/patient-safety-alerts/

National Reporting & Learning System: email: patientsafetyhelpdesk@nrls.nhs.uk

The Chief Medical Officer (for England): https://www.gov.uk/government/people/sally-davies

When we provide services, we want to make them easy, useful and reliable. Where services are delivered on the internet, this sometimes involves placing small amounts of information on your device, for example, computer or mobile phone. These include small files known as cookies. They cannot be used to identify you personally. More Information can be found in the Help section under Cookie usage.

Our updated privacy notice can be found here.



EL (18)A/17 Class 2 Alert: Teva Uk Limited: Valsartan 40mg And 320mg Film-Coated Tablets; Valsartan/Hydrochlorothiazide 80/12.5mg, 160/12.5mg And 160/25mg Film-Coated Tablets. Mylan: Valsartan 40mg, 80mg And 160mg Capsules; Valsartan 40mg And 320mg Film-Coated Tablets. This alert was issued twice due to human error. We apologise for any inconvenience caused. CAS Liaison Officers please action the alert as normal. (Added 3 December 2018).

MDA/2018/035: All T34 Ambulatory syringe pumps - update concerning battery information. Please note that the action completed date on the P ...
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Contact our helpdesk

Telephone: 020 3080 6747
Email: safetyalerts@mhra.gov.uk

Medicines and Healthcare products Regulatory Agency