Central Alerting System Homepage


The Central Alerting System (CAS) is a web-based cascading system for issuing patient safety alerts, important public health messages and other safety critical information and guidance to the NHS and others, including independent providers of health and social care.

Alerts available on the CAS website include NHS Improvement Patient Safety Alerts (PSA) and Estates Alerts, MHRA Dear Doctor letters, Medical Device Alerts (MDA) and Drug Alerts, Chief Medical Officer (CMO) Alerts, and Department of Health & Social Care Supply Disruption alerts.

Useful links:

The Medicines and Healthcare products Regulatory Agency: http://gov.uk/mhra

NHS Improvement: https://improvement.nhs.uk/resources/patient-safety-alerts/

National Reporting & Learning System (email): patientsafetyhelpdesk@nrls.nhs.uk

The Chief Medical Officer (for England): https://www.gov.uk/government/people/christopher-whitty

When we provide services, we want to make them easy, useful and reliable. Where services are delivered on the internet, this sometimes involves placing small amounts of information on your device, for example, computer or mobile phone. These include small files known as cookies. They cannot be used to identify you personally. More Information can be found in the Help section under Cookie usage.

Our updated privacy notice can be found here.


EL (19)A/28 - we have amended the alert pdf as it had the incorrect date of issue at the top. No other changes have been made.

MDA/2019/023 (20 September 2019) – Please note that under ‘Action’, points 2 and 3 have been amended; whilst under ‘Problem/background’, the first bullet point in the fifth paragraph has been amended and a references added. It can be accessed at the link below.

https://www.gov.uk/drug-device-alerts/recommendations-for-ongoing-use-of-paclitaxel-drug-coated-balloons-dcbs-and-implantable-drug-eluting-stents-dess-in-the-treatment-of-patients-with-peripheral-artery-dis ...
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Contact our helpdesk

Email: safetyalerts@mhra.gov.uk

Medicines and Healthcare products Regulatory Agency