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Originator: National Patient Safety Alert - DHSC

Issue date: 02-Dec-2025 10:50:52

This alert has been issued to:
  • Care Trusts
  • Mental Health Trusts
  • Specialists Trusts
  • Learning Disabilities Trusts
  • Mental Health & Social Care Trusts
  • Ambulance Trusts
  • Mental Health & Learning Disabilities Trusts
  • Acute Trusts
  • Community Trusts

  • Other contacts
  • Independent Healthcare Providers (registered with CAS)
  • Clinical Commissioning Groups
  • Special Health Authorities
  • Territorial CMOs in Northern Ireland, Scotland & Wales
  • Integrated Care Boards
  • DHSC Supply Disruption - Medicines

Action category: Action

Title: Supply of Licensed and Unlicensed Epidural Infusion Bags

Broadcast content:

There are supply issues affecting epidural bags from Sandoz (licensed) and Fresenius Kabi (unlicensed) containing:

·  bupivacaine only

·  bupivacaine and fentanyl

·  levobupivacine and fentanyl.

A range of alternative licensed and unlicensed bags (including unlicensed imports) are available during the affected period expected to last until at least March 2026, but the use of these products will require a co-ordinated trust wide approach to ensure safe implementation.


This National Patient Safety Alert provides further background, clinical information and actions for providers.



Additional information: This alert is not relevant to primary care.

Alert reference: NatPSA/2025/007/DHSC

Action underway deadline: 04-Dec-2025

Action complete deadline: 12-Dec-2025

Attachments:

Contact our helpdesk

Email: safetyalerts@mhra.gov.uk

Medicines and Healthcare products Regulatory Agency