Central Alerting System
View Alert

Originator: National Patient Safety Alert - DHSC

Issue date: Originally issued on 18-Jul-2023 08:46:03. This version was issued on 18-Jul-2023 08:46:03

This alert has been issued to:
  • Care Trusts
  • Mental Health Trusts
  • Specialists Trusts
  • Learning Disabilities Trusts
  • Mental Health & Social Care Trusts
  • Ambulance Trusts
  • Mental Health & Learning Disabilities Trusts
  • Acute Trusts
  • Community Trusts

  • Other contacts
  • Independent Healthcare Providers (registered with CAS)
  • Clinical Commissioning Groups
  • NHS Regional Offices
  • Social Care Providers (registered with CAS)
  • Special Health Authorities
  • Territorial CMOs in Northern Ireland, Scotland & Wales
  • Regional Directors of Public Health
  • Director of Public Health
  • GP - Locum
  • NHS 111 and Out of hours providers
  • GP Practices
  • DHSC Supply Disruption - Medicines
  • Community Pharmacy
  • Primary Care Networks
  • GP Practices 1

Action category: Action

Title: Shortage of GLP-1 receptor agonists

Broadcast content: ***Please note this alert has been superseded by NatPSA/2024/001/DHSC, issued 03/01/2024***

There are very limited, intermittent supplies of all glucagon-like peptide-1 receptor agonists (GLP-1 RAs).

Supplies are not expected to stabilise to meet full market demand until at least mid-2024. 

The supply issues have been caused by an increase in demand for these products for licensed and off-label indications.

The off-label use of these agents for the management of obesity is strongly discouraged. Existing stock must be conserved for use in patients with diabetes. These shortages have serious clinical implications in the management of patients with type 2 diabetes. 

This National Patient Safety Alert provides further background and clinical information and actions for providers.

*** 28 September 2023: the original alert pdf has been updated to amend the wording under action 3. i. to refer to NICE NG28. This replaces the incorrect reference to NICE CG28 in the original pdf. No other changes have been made.***

Additional information: NHS England Regions: please cascade this National Patient Safety Alert to community pharmacy.

Alert reference: NatPSA/2023/008/DHSC

Action underway deadline: 28-Sep-2023

Action complete deadline: 18-Oct-2023


Contact our helpdesk

Email: safetyalerts@mhra.gov.uk

Medicines and Healthcare products Regulatory Agency