There will be supply constraints facing alteplase (Actilyse®) 10mg, 20mg and 50mg injections for the remainder of 2022. Tenecteplase (Metalyse®) 10,000unit injections will go out of stock in the coming months. At present the situation is expected to improve in early 2023.
This National Patient Safety Alert contains further information and actions for providers.
***06 October***: the supply situation of alteplase has since improved. A Medicines Supply Notification has been published which supersedes the management advice provided in this National Patient Safety Alert. This notification can be accessed via this link.