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Originator: DHSC & NHS England and Improvement: Supply disruption alert

Issue date: 25-Nov-2021 18:37:09

This alert has been issued to:
  • Care Trusts
  • Mental Health Trusts
  • Learning Disabilities Trusts
  • Mental Health & Social Care Trusts
  • Ambulance Trusts
  • Acute Trusts
  • Community Trusts

  • MHRA (Medicines) Drug Alerts (Various Recipients)
  • Other contacts
  • Independent Healthcare Providers (registered with CAS)
  • Clinical Commissioning Groups
  • NHS Regional Offices
  • Social Care Providers (registered with CAS)
  • MHRA (Medicines) Drug Alerts - Non-NHS Recipients
  • Mental Health & Learning Disabilities Trusts
  • Territorial CMOs in Northern Ireland, Scotland & Wales
  • GP - Locum
  • NHS 111 and Out of hours providers
  • GP Practices
  • DHSC Supply Disruption - Medicines
  • Community Pharmacy
  • Primary Care Networks
  • GP Practices 1

Action category: Action

Title: Hypovase (prazosin) 500 microgram tablets - Supply disruption

Broadcast content:

Hypovase® (prazosin) 500 microgram tablets will be out of stock from late November 2021 until mid-January 2022. Pfizer are the sole supplier of prazosin 500 microgram tablets in the UK.

Prescribers will need to review all affected patients to discuss management plans.

Alternative alpha blockers remain available and can support an uplift in demand.

Unlicensed supplies of prazosin 500microgram tablets have been sourced and may be considered where the above option is inappropriate.

This alert contains further information and action for providers.

Please note that no response is required via the CAS website to this alert.

Additional information: NHS England and NHS Improvement Offices: please cascade this alert to Community Pharmacy

Alert reference: SDA/2021/015


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Email: safetyalerts@mhra.gov.uk

Medicines and Healthcare products Regulatory Agency