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Originator: DHSC & NHS England and Improvement: Supply disruption alert

Issue date: Originally issued on 21-Aug-2020 08:30:19. This version was issued on 21-Aug-2020 08:30:19

This alert has been issued to:
  • Care Trusts
  • Mental Health Trusts
  • Specialists Trusts
  • NHS Regional Offices
  • Learning Disabilities Trusts
  • Mental Health & Social Care Trusts
  • Ambulance Trusts
  • Mental Health & Learning Disabilities
  • Acute Trusts
  • Community Trusts

  • MHRA (Medicines) Drug Alerts (Various Recipients)
  • Other contacts
  • Independent Healthcare Providers (registered with CAS)
  • Clinical Commissioning Groups
  • Social Care Providers (registered with CAS)
  • Special Health Authorities
  • MHRA (Medicines) Drug Alerts - Non-NHS Recipients
  • GP - Locum
  • NHS 111 and Out of hours providers
  • GP Practices
  • DHSC Supply Disruption - Medicines
  • Primary Care Networks
  • GP Practices 1

Action category: Action

Title: Lithium carbonate (Priadel) 200mg and 400mg modified release tablets - Supply Disruption

Broadcast content:
15 September 2020, we have made a further update to the alert pdf on page 2:

  • Prescribers should ensure that all patients have a ‘Lithium treatment pack’. The pack consists of a patient information booklet, lithium alert card, and a record book for tracking serum-lithium concentration. Packs can be ordered from via tel:-0845 610 1112, online:- www.nhsforms.co.uk (secondary care) or tel:- 0333 0142884, online:- pcse.england.nhs.uk/services/supplies/ (primary care).

25 August 2020: we have updated the alert pdf, which has a change on page 2 to the bullet point about the Lithium treatment pack, this now reads:

  • Prescribers should ensure that all patients have a ‘Lithium treatment pack’. The pack consists of a patient information booklet, lithium alert card, and a record book for tracking serum-lithium concentration. (Packs can be ordered from 3M Tel:- 0845 610 1112 or online primary care- https://pcse.england.nhs.uk/services/supplies/ and secondary care- http://www.nhsforms.co.uk/) 


Priadel® (lithium carbonate) 200mg and 400mg modified-release tablets are being discontinued in the UK and remaining supplies of both strengths are expected to be exhausted by April 2021.

Lithium (Priadel®, Camcolit® and Liskonum® brands) is a first line treatment for patients with bipolar disorder. It is also licensed for the treatment and prophylaxis of recurrent depression, and aggressive or self-harming behaviour, and used off-license in the treatment of cluster headaches.

Clinical guidance advises that patients must be maintained on the same brand of lithium to ensure that a consistent serum lithium level is maintained. The switching of brands necessitated by this SDA will require individualised determination of dose, close monitoring of serum lithium levels and vigilance for relapse and tolerability in all cases.

This alert contains advice on the management of impacted patients.

Please note that no response is required via the CAS website to this alert.



Additional information: NHS England and NHS Improvement Regional Offices: please cascade this alert to Community Pharmacy.

Alert reference: SDA/2020/012

Attachments:

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Email: safetyalerts@mhra.gov.uk

Medicines and Healthcare products Regulatory Agency