This alert contains actions which are in addition to those outlined in the National Patient Safety Alert (NatPSA/2024/007/DHSC) issued on 24th May 2024. 

There are limited supplies of pancreatic enzyme replacement therapies (PERT). 

• Creon® 10,000 and 25,000 capsules remain in limited supply until 2026. 

• Nutrizym® 22 capsules and Pancrex V® capsules and powder are intermittently available but are unable to fully cover the gap in supply

This  National Patient Safety Alert provides further background, clinical information and actions for providers.