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Originator: DHSC & NHS England and Improvement: Supply disruption alert

Issue date: Originally issued on 29-May-2020 10:21:38. This version was issued on 29-May-2020 10:21:38

This alert has been issued to:
  • Care Trusts
  • Mental Health Trusts
  • Specialists Trusts
  • NHS Regional Offices
  • Learning Disabilities Trusts
  • Mental Health & Social Care Trusts
  • Ambulance Trusts
  • Mental Health & Learning Disabilities Trusts
  • Acute Trusts
  • Community Trusts

  • MHRA (Medicines) Drug Alerts (Various Recipients)
  • Other contacts
  • Independent Healthcare Providers (registered with CAS)
  • Clinical Commissioning Groups
  • MHRA (Medicines) Drug Alerts - Non-NHS Recipients
  • GP - Locum
  • NHS 111 and Out of hours providers
  • GP Practices
  • DHSC Supply Disruption - Medicines
  • Primary Care Networks

Action category: Action

Title: Danazol 100mg and 200mg capsules - Supply Disruption

Broadcast content:
Danazol 100mg and 200mg capsules have been discontinued in the UK and remaining supplies of both strengths are now exhausted.

Danazol has several licensed indications and off-label uses. The management of patients prescribed danazol for licensed indications will differ to those prescribed danazol for an off-label use.

A limited quantity of unlicensed supplies of danazol 100mg and 200mg capsules have been sourced. 

This alert contains advice on the management of affected patients.

Please note that no response is required via the CAS website to this alert.

We have updated the alert pdf to amend a link to the Breast Pain clinical knowledge summary in the 'Advice on switching patients to alternative therapies' section.

Additional information: NHS England and NHS Improvement Regional Offices: please cascade this alert to community pharmacy.

Alert reference: SDA/2020/009


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Email: safetyalerts@mhra.gov.uk

Medicines and Healthcare products Regulatory Agency