**05 April 2024: we have updated the pdf to rectify some formatting issues and broken links.**
Transfusion-associated circulatory overload (TACO) is
defined as acute or worsening respiratory compromise
and/or acute or worsening pulmonary oedema during or
up to 12 hours after transfusion, with additional features
including cardiovascular system changes not explained
by the patient’s underlying medical condition, evidence
of fluid overload and a relevant biomarker.
TACO is
one of the most common causes of transfusion related deaths in the UK and cases have increased
substantially in recent years. Identifying risk
factors for TACO prior to transfusion allows
initiation of appropriate mitigating measures.
This National Patient Safety Alert contains further information and action for providers to reduce risks for patients.